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Homeopathy: Medicine for the 21st Century

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Defending Choice in Medicine

H:MC21 is a charity established to counter the unfounded propaganda against homeopathy by informing the public of the facts about homeopathy and its historical and scientific relationship to orthodox medicine.

It will do this through research, publication and campaigning.

Clicking on the links below will take you directly to various aspects of our campaign

Follow us on Twitter at @HMC21org

Publications

Nonsense, Not Science

 Halloween Science

Pilot survey of PCTs

Edzard Ernst interview

 Resource pack

CS&TC Report

CS&CT Evidence Check

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Charity no. 1124711
Registered address: Poppyseed Cottage,
High Street, Stoke Ferry, Norfolk PE33 9SF

What is the placebo effect?

The most important point to remember about the placebo effect is that it is simply the name given to a collection of observed events, the causes of which are unknown. Indeed it is not even known how many causes are involved. As such the placebo effect is not a scientifically defined process, and the terms 'placebo' and 'placebo effect' can often be used in ways which cause confusion. One common and serious example of this confusion is the fact that the term 'placebo effect' can be used to mean two different things.

Actual changes
It has been observed that real changes in health can occur in people who believe that they are having a treatment, when in fact the procedure or medication is considered to be inactive. Because this was first observed in patients who felt that they had benefited, the response was called ‘the placebo effect’ (from the Latin ‘I shall please’). Similarly, symptoms of damage can occur when a person believes that they are being harmed, and this is sometimes called ‘the nocebo effect’. In both these cases, if the person is subsequently made aware of the fact that they have received an inactive treatment, the changes can revert to the former state.

The important point about this effect is that real changes take place.

Imagined changes
The term is also often used to refer to a similar but significantly different effect, where a person feels better after an ‘inactive’ treatment, but presents no observable change.

Confusion
The confusion of these two different types of reaction not only shows a lack of scientific clarity about the placebo effect, but is often deliberately used to mislead people by

  • Implying that the placebo effect is illusory;
  • Equating the placebo effect with other emotional responses;
  • Ignoring the need to explain how it leads to highly specific real changes in health.

    • The last of these is of particular importance, since the placebo effect is often used as a 'scientific' explanation of the success of complementary and alternative medicine.

      In fact scientists are unable to offer an explanation of the actual mechanism by which a person’s expectations of the results of the treatment can produce an enormously wide range of specific changes. Furthermore they are unable to distinguish between the placebo effect and the effect of an active substance other than by knowing which treatment was given in each case. In other words this 'scientific' explanation is itself scientifically inexplicable.

      Its use in trials
      The existence of the placebo effect has meant that trials of medical treatments have to take into account benefits not attributable to the intervention being tested. As a result the randomised controlled trial (RCT) has been developed, where the effects of a treatment are compared with those of an ‘inactive’ version in order to establish whether the treatment produces a benefit over and above any placebo effect. The problem is that because the mechanism of action of the placebo effect is unknown, there can be no certainty about whether all the relevant factors have been taken into account.

      When it comes to testing homeopathic treatment, there are further complications. Homeopathy is practised according to 'laws' which govern the relationship of treatment to the patient's illness, including what can actually be treated at a particular time. Thus:

      • If the treatment is not appropriately individualised in some cases, then in those cases a placebo would be being tested instead of a treatment.
      • If the treatment was trying to treat conditions in the wrong order in some cases, then in those cases a placebo would be being tested instead of a treatment.

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